Lamina, also known as nuclear lamina, is a mesh-like structure that lines the inner surface of the nuclear envelope in eukaryotic cells. Composed of intermediate filaments and associated proteins, the lamina provides structural support and maintains the shape of the nucleus. It also plays a role in regulating gene expression and DNA replication.
The main function of the lamina is to provide mechanical support to the nucleus and anchor the chromatin to the nuclear envelope. Additionally, it helps in organizing the chromatin and regulating its accessibility to transcription factors and other nuclear components.
Defects in the lamina have been linked to various genetic disorders, including progeria and muscular dystrophy, highlighting its importance in maintaining cellular homeostasis. Understanding the structure and function of the lamina is crucial for unraveling the complexities of nuclear organization and gene regulation in eukaryotic cells.#16#