The lamina is a mesh-like structure located beneath the inner nuclear membrane of eukaryotic cells. Composed of intermediate filaments and associated proteins, the lamina provides structural support to the nucleus and anchors chromatin. It also plays a key role in regulating gene expression and maintaining nuclear shape. Mutations in lamina proteins have been linked to various genetic disorders, including muscular dystrophy and premature aging syndromes.
Furthermore, the lamina is involved in nuclear pore complex assembly and regulates the movement of molecules in and out of the nucleus. It also interacts with the cytoskeleton, contributing to cell migration and division. Overall, the lamina is essential for maintaining the structural integrity of the nucleus and ensuring proper cellular function. Its study continues to provide valuable insights into the complex mechanisms of biology.#16#